大鼠饥饿或食物限制后的体重恢复

Recovery of body weight following starvation or food restriction in rats.

作者信息

Penicaud L, Le Magnen J

出版信息

Neurosci Biobehav Rev. 1980;4 Suppl 1:47-52. doi: 10.1016/0149-7634(80)90048-2.

Abstract

Recovery of body weight and food intake have been studied and compared after a 25% weight loss produced by total starvation in one group of rats or by food restriction in a second group. It was shown that rats in both groups returned to their initial body weight within the same time on the average, but the hyperphagia observed during the recovery phase was significantly higher in restricted than in starved rats. In the former, the increase of food intake fully accounted for the weight gain. On the contrary, the recovery of body weight in previously starved rats involved both hyperphagia and a long lasting persistence of the fasting hypometabolism. In addition, it was shown that in those rats the higher the contribution of hypometabolism the longer the recovery. Starvation diabetes was higher in starved than in restricted rats and might be one factor which impairs weight regulation through hyperphagia after a weight loss induced by food deprivation.

摘要

对两组大鼠体重减轻后的体重恢复和食物摄入量进行了研究和比较。其中一组大鼠通过完全饥饿使体重减轻25%，另一组则通过食物限制使体重减轻25%。结果表明，两组大鼠平均在相同时间内恢复到初始体重，但在恢复阶段观察到的食欲亢进在食物限制组大鼠中显著高于饥饿组大鼠。在食物限制组大鼠中，食物摄入量的增加完全解释了体重的增加。相反，先前饥饿的大鼠体重恢复既涉及食欲亢进，又涉及禁食低代谢的长期持续存在。此外，研究表明，在这些大鼠中，低代谢的贡献越高，恢复时间越长。饥饿性糖尿病在饥饿组大鼠中比在食物限制组大鼠中更严重，可能是在食物剥夺导致体重减轻后通过食欲亢进损害体重调节的一个因素。