Harris R B, Kasser T R, Martin R J
J Nutr. 1986 Dec;116(12):2536-46. doi: 10.1093/jn/116.12.2536.
In this study we examined the body composition of rats recovering from overfeeding, underfeeding or starvation. Female rats (220 g) were fed 160%, 100% or 40% of control intake, by stomach tube, until the 40% rats had lost 50 g. Other rats were starved to lose 50 g. Carcass composition was measured on one group from each treatment. The remaining rats returned to ad libitum feeding. The 160% rats were hypophagic and lost weight. Starved and 40% rats were hyperphagic and gained weight. Serum insulin increased with increased food intake. T4 was depressed by food restriction. T3 and T4 increased during weight loss in 160% rats. Carcass composition of rats from each treatment was determined at progressive stages of recovery. Overfed rats had gained 7 g of protein and 43 g of fat. Protein was soon lost but fat was still significantly increased after 44 d of recovery. Starved and restricted rats had lost 11 g of protein and 28 g of fat. Starved rats regained protein earlier than body fat. Restricted rats recovered body fat much earlier than body protein or weight. Body protein and fat may have individual regulatory mechanisms that work together to control body weight.
在本研究中，我们检测了从过度喂养、喂养不足或饥饿状态恢复的大鼠的身体组成。将雌性大鼠（220克）通过胃管分别给予对照摄入量的160%、100%或40%，直到摄入40%的大鼠体重减轻50克。其他大鼠则饥饿至体重减轻50克。对每种处理的一组大鼠测量其胴体组成。其余大鼠恢复自由进食。摄入160%的大鼠摄食量减少且体重减轻。饥饿和摄入40%的大鼠摄食量增加且体重增加。血清胰岛素随食物摄入量增加而升高。甲状腺素（T4）因食物限制而降低。在摄入160%的大鼠体重减轻期间，三碘甲状腺原氨酸（T3）和T4升高。在恢复的不同阶段测定每种处理大鼠的胴体组成。过度喂养的大鼠增加了7克蛋白质和43克脂肪。蛋白质很快流失，但在恢复44天后脂肪仍显著增加。饥饿和食物受限的大鼠分别流失了11克蛋白质和28克脂肪。饥饿的大鼠蛋白质比体脂恢复得早。食物受限的大鼠体脂比身体蛋白质或体重恢复得早得多。身体蛋白质和脂肪可能具有共同控制体重的各自独立的调节机制。
