Hustinx T W, Burghouts J T, Scheres J M, Smits A P
Cancer. 1980 Jan 15;45(2):285-8. doi: 10.1002/1097-0142(19800115)45:2<285::aid-cncr2820450214>3.0.co;2-6.
The clinical, hematological, and cytogenetic characteristics of a male patient with AMMoL are described. Before treatment a clone with the complex karyotype 45,X,del(7)(q32), t(8;21)(q22;q22) was present in the bone marrow. During partial remission induced by cytostatics, the percentage of normal cells increased, and a cell line having a 46,XY,del(7)(q32) karyotype was found. After four therapy courses, when remission was complete, only chromosomally normal cells were seen. The cytogenetic data suggest that in this case the 8/21 translocation and loss of the Y chromosome were only secondary events.
描述了一名急性单核细胞白血病男性患者的临床、血液学和细胞遗传学特征。治疗前，骨髓中存在复杂核型为45,X,del(7)(q32), t(8;21)(q22;q22)的克隆。在细胞抑制剂诱导的部分缓解期间，正常细胞百分比增加，并发现了核型为46,XY,del(7)(q32)的细胞系。四个疗程治疗后，当完全缓解时，仅见染色体正常的细胞。细胞遗传学数据表明，在该病例中，8号与21号染色体易位及Y染色体丢失只是继发事件。
