伴有t(8;21)易位的急性髓系白血病：7例细胞遗传学研究
Acute myelogenous leukemia with translocation t(8;21): a cytogenetic study of seven cases.
作者信息
Sessarego M, Mareni C, Panarello C, Garrè L, Frassoni F, Boccaccio P, Ajmar F
出版信息
Cancer Genet Cytogenet. 1986 Feb 15;20(3-4):363-8. doi: 10.1016/0165-4608(86)90096-8.
Seven cases of acute nonlymphoblastic leukemia showing t(8;21)(q22;q22) at diagnosis are described. Involvement of a sex chromosome was found in all patients (in six cases as a loss, and in one as a Y duplication), thus, confirming the suggestion of a correlation between these two chromosomal abnormalities. The constitutional folic acid-sensitive fragile site fra(8)(q22) was not detected, in spite of careful analysis of over 300 metaphases of cells grown in folic acid-free medium. Morphologic diagnoses and clinical aspects are briefly discussed.
本文描述了7例诊断时显示t(8;21)(q22;q22)的急性非淋巴细胞白血病病例。所有患者均发现有性染色体受累（6例为缺失，1例为Y染色体重复），从而证实了这两种染色体异常之间存在相关性的推测。尽管对在无叶酸培养基中生长的细胞的300多个中期相进行了仔细分析，但未检测到构成性叶酸敏感脆性位点fra(8)(q22)。文中简要讨论了形态学诊断和临床情况。
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