Hammouda O, Seif M, Brinkley B, Dabbous M K, Jurand J
J Dent Res. 1980 Jan;59(1):17-22. doi: 10.1177/00220345800590010201.
The isolation and characterization of cyanogen bromide peptides derived from the human gingival collagen of patients with chronic periodontitis revealed the presence of both Type I and Type III collagens in this tissue. The amount of TYPE III collagen, however, was found to be lower than that in normal gingival tissue. In addition, a non-collagenous protein fraction, accounting for approximately 20% of the insoluble matrix, was relatively rich in acidic, hydrophobic, and hydroxy-containing amino acids. Amino acid analysis, likewise, revealed qualitative and quantitative differences between the normal and diseased tissues.
对慢性牙周炎患者人牙龈胶原蛋白衍生的溴化氰肽进行分离和特性分析后发现，该组织中同时存在I型和III型胶原蛋白。然而，发现III型胶原蛋白的含量低于正常牙龈组织。此外，一种占不溶性基质约20%的非胶原蛋白部分富含酸性、疏水性和含羟基氨基酸。同样，氨基酸分析揭示了正常组织和患病组织之间在定性和定量方面的差异。
