肿瘤内雌激素硫酸酯酶活性作为人类乳腺癌的预后标志物
Intratumoral oestrone sulphatase activity as a prognostic marker in human breast carcinoma.
作者信息
Evans T R, Rowlands M G, Law M, Coombes R C
机构信息
Department of Medical Oncology, St George's Hospital Medical School, London, UK.
出版信息
Br J Cancer. 1994 Mar;69(3):555-61. doi: 10.1038/bjc.1994.101.
Abstract
Oestrone sulphatase is an important source of local synthesis of biologically active oestrogens in human breast cancer. The oestrone sulphatase enzyme in the particulate fraction of human breast carcinoma was characterised. The Km was 8.91 microM, and the Vmax was 0.022 nmol min-1 mg-1. Oestrone sulphatase activity was detected in 93 of 104 human breast carcinoma samples (89%), and mean activity was 0.041 nmol min-1 mg-1 (range 0-0.399 nmol min-1 mg-1). There was no significant correlation between intratumoral oestrone sulphatase activity and oestrogen receptor status, or with any other prognostic factors. Intratumoral enzyme levels were not associated with time to recurrence or with overall survival time. It thus appears that, although a useful source of intratumoral oestrogens, oestrone sulphatase activity is not of prognostic significance in breast carcinoma.
摘要
硫酸雌酮酶是人类乳腺癌中生物活性雌激素局部合成的重要来源。对人乳腺癌微粒体部分中的硫酸雌酮酶进行了特性分析。其米氏常数（Km）为8.91微摩尔，最大反应速度（Vmax）为0.022纳摩尔·分钟-1·毫克-1。在104例人乳腺癌样本中的93例（89%）检测到硫酸雌酮酶活性，平均活性为0.041纳摩尔·分钟-1·毫克-1（范围为0 - 0.399纳摩尔·分钟-1·毫克-1）。肿瘤内硫酸雌酮酶活性与雌激素受体状态或任何其他预后因素之间无显著相关性。肿瘤内酶水平与复发时间或总生存时间无关。因此，尽管硫酸雌酮酶活性是肿瘤内雌激素的一个有用来源，但它在乳腺癌中并无预后意义。
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