Thibadoux G M, Pereira W V, Hodges J M, Aur R J
J Pediatr. 1980 Mar;96(3 Pt 1):403-6. doi: 10.1016/s0022-3476(80)80681-0.
We serially assessed the hearing sensitivity of 61 children with acute lymphocytic leukemia who were admitted to our Total Therapy IX study between December, 1975, and July, 1977. Their treatment included combined chemotherapy, 2,400 rads of cranial radiation, and intrathecal methotrexate. Subjects initially received an otologic examination and middle ear function testing. Audiometric testing was not done until ears were free of outer or middle ear pathology. If the child had no outer or middle ear disease, audiometric thresholds were obtained for the test frequencies: 500, 1,000, 2,000, 4,000, 6,000, and 8,000 Hz. Pure-tone thresholds were obtained before irradiation (61 patients) and at 6, 12, and 36 months thereafter (49, 46, and 22 patients, respectively). The median age at time of baseline testing was 10 years, 2 months. A paired sample test based on group data was used to test whether there were any significant changes from the threshold values at 6, 12, and 36 months after irradiation. Thresholds were not significantly affected for any test frequency at any test time. Assessments of individual audiograms indicated that none of the children had any significant reductions in hearing levels at the end of the third year after cranial irradiation.
我们对1975年12月至1977年7月期间参加我们第九期全面治疗研究的61名急性淋巴细胞白血病患儿的听力敏感性进行了连续评估。他们的治疗包括联合化疗、2400拉德的颅脑放疗以及鞘内注射甲氨蝶呤。研究对象最初接受了耳科检查和中耳功能测试。直到耳朵没有外耳或中耳病变时才进行听力测试。如果患儿没有外耳或中耳疾病，则获取测试频率为500、1000、2000、4000、6000和8000赫兹时的听力阈值。在放疗前（61例患者）以及放疗后6个月、12个月和36个月（分别为49例、46例和22例患者）获取纯音阈值。基线测试时的中位年龄为10岁2个月。基于组数据的配对样本检验用于测试放疗后6个月、12个月和36个月时的阈值与初始值相比是否有任何显著变化。在任何测试时间的任何测试频率下，阈值均未受到显著影响。对个体听力图的评估表明，在颅脑放疗后的第三年末，没有患儿的听力水平出现任何显著下降。
