Hunt S C, Williams R R, Skolnick M H, Lyon J L, Smart C R
J Natl Cancer Inst. 1980 May;64(5):1047-53.
With the use of data from the Utah State Cancer Registry and Utah genealogical data, an analysis of 236 breast cancer patients and 937 controls matched on year of birth showed that a late age at the birth of the first child was most strongly associated with incidence of breast cancer (relative odds = 2.0; P less than 0.001). A strong interaction was found between age at first delivery (AFD) and age at last delivery (ALD). The association of AFD with breast cancer incidence was strongest for women with an ALD before 35 years of age even after adjustment for partly (relative odds = 4.1; P less than 0.001). Decreased parity was not significantly associated with breast cancer.
利用犹他州癌症登记处的数据和犹他州的族谱数据，对236例乳腺癌患者和937例按出生年份匹配的对照进行分析，结果显示，头胎出生时年龄较大与乳腺癌发病率的关联最为强烈（相对比值=2.0；P<0.001）。首次分娩年龄（AFD）和末次分娩年龄（ALD）之间存在强烈的相互作用。即使在部分调整后，对于末次分娩年龄在35岁之前的女性，AFD与乳腺癌发病率的关联仍然最强（相对比值=4.1；P<0.001）。生育次数减少与乳腺癌无显著关联。
