Frauenklinik Nathanstift and Breast Cancer Centre Fürth, Germany.
Carl-Gustav-Carus Medical School, Technical University Dresden, Germany.
Breast Care (Basel). 2014 Dec;9(6):398-405. doi: 10.1159/000369570.
Reproduction is doubtlessly one of the main biological meanings of life. It is therefore not surprising that various aspects of reproduction impact on breast cancer risk. Various developmental levels may become targets of breast tumorigenesis. This review follows the chronologic sequence of events in the life of a female at risk, starting with the intrauterine development. Furthermore, the influence of both contraceptive measures and fertility treatment on breast cancer development is dealt with, as well as various pregnancy-associated factors, events, and perinatal outcomes. Finally, the contribution of breast feeding to a reduced breast cancer risk is discussed.
生殖无疑是生命的主要生物学意义之一。因此，生殖的各个方面都会影响乳腺癌的风险也就不足为奇了。各种发育阶段都可能成为乳腺癌发生的靶点。这篇综述按照女性在风险期的生命历程的时间顺序进行，从子宫内发育开始。此外，还涉及了避孕措施和生育治疗对乳腺癌发展的影响，以及各种与妊娠相关的因素、事件和围产期结局。最后，讨论了母乳喂养对降低乳腺癌风险的贡献。
