Caldarelli D D, Hutchinson J G, Pruzansky S, Valvassori G E
Cleft Palate J. 1980 Apr;17(2):103-10.
A number of entities can be categorized as otocraniofacial syndromes. New clinical and laboratory studies have demonstrated predictable patterns of occurrence, distinct anatomic interrelationships, separate genetic predispositions, and animal models of the varied embryogeneses. These investigations have allowed clinical separation of first and second branchial arch anomalies into syndromes of hemifacial microsomia and mandibulofacial dysostosis. The present study has established a relationship between the severity of the microtic auricle and middle ear malformation in those syndromes. Middle ear deformities, while present in both, are more severe when associated with mandibulofacial dysostosis.
许多病症可归类为耳颅面综合征。新的临床和实验室研究已经证实了其可预测的发病模式、独特的解剖学相互关系、不同的遗传易感性以及各种胚胎发育过程的动物模型。这些研究使得临床能够将第一和第二鳃弓异常区分为半侧颜面短小综合征和下颌面骨发育不全综合征。本研究已经确立了这些综合征中微小耳郭与中耳畸形严重程度之间的关系。中耳畸形在这两种综合征中均有出现，但与下颌面骨发育不全相关时更为严重。
