Housholder G T, Moorrees L L
J Oral Surg. 1980 Jun;38(6):412-6.
Fibrinolytic parameters were compared in blood taken from rats treated with aspirin (10 and 40 mg/kg) or saline solution. Plasma euglobulin fractions prepared from animals treated with the higher dose of aspirin caused increased zones of lysis on plasminogen-rich fibrin plates. Even greater lytic activity was detected in blood from all aspirin-treated rats when euglobulin fractions were augmented with sodium flufenamate and dextran sulfate. The inhibitor index was significantly reduced when calculated for rats treated with the larger dose of drug. Dilute blood clot lysis times for this group were consistently prolonged, most likely reflecting impaired platelet function. Platelet counts, hematocrits, and bleeding times did not differ from controls. Prothrombin times, activated partial thromboplastin times, and plasma clot times were all prolonged, reflecting the sensitivity of the vitamin K-dependent factors to aspirin.
对用阿司匹林（10毫克/千克和40毫克/千克）或生理盐水处理的大鼠所采集血液中的纤溶参数进行了比较。从接受较高剂量阿司匹林处理的动物制备的血浆优球蛋白组分，在富含纤溶酶原的纤维蛋白平板上导致溶解区域增加。当用氟芬那酸钠和硫酸葡聚糖增强优球蛋白组分时，在所有接受阿司匹林处理的大鼠血液中检测到更高的溶解活性。当计算接受较大剂量药物处理的大鼠的抑制剂指数时，该指数显著降低。该组的稀释血凝块溶解时间持续延长，很可能反映了血小板功能受损。血小板计数、血细胞比容和出血时间与对照组无差异。凝血酶原时间、活化部分凝血活酶时间和血浆凝固时间均延长，反映了维生素K依赖因子对阿司匹林的敏感性。
