脂质对乳腺细胞系分化的调控
Control of differentiation of a mammary cell line by lipids.
作者信息
Dulbecco R, Bologna M, Unger M
出版信息
Proc Natl Acad Sci U S A. 1980 Mar;77(3):1551-5. doi: 10.1073/pnas.77.3.1551.
Abstract
A rat mammary cell line (LA7) undergoes spontaneous differentiation into domes due to production of specific inducers by the cells. Some of these inducers may be lipids, and we show that lipids regulate this differentiation as both inducers and inhibitors. One inhibitor is the tumor promoter tetradecanoyl-13 phorbol 12-acetate. The inducers are saturated fatty acids of two groups: butyric acid and acids with chain lengths from C13 to C16, especially myristic acid (C14). Other inducers are myristoyl and palmitoyl lysolecithins, myristic acid methyl ester, and two cationic detergents with a tetradecenyl chain. We propose that the lipids with a C14-C16 alkyl chain affect differentiation by recognition specific receptors through their alkyl chains and that the effects obtained depend on the head groups. These lipids may be physiological regulators in the mammary gland.
摘要
一种大鼠乳腺细胞系（LA7）由于细胞产生特定诱导剂而自发分化形成穹顶。其中一些诱导剂可能是脂质，我们发现脂质作为诱导剂和抑制剂调节这种分化。一种抑制剂是肿瘤促进剂十四烷酰-13佛波醇12-乙酸酯。诱导剂是两类饱和脂肪酸：丁酸和链长从C13到C16的酸，尤其是肉豆蔻酸（C14）。其他诱导剂是肉豆蔻酰和棕榈酰溶血卵磷脂、肉豆蔻酸甲酯以及两种带有十四碳烯基链的阳离子去污剂。我们提出，具有C14 - C16烷基链的脂质通过其烷基链识别特定受体来影响分化，并且所获得的效果取决于头部基团。这些脂质可能是乳腺中的生理调节剂。
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