在个体发育过程中，携带Ia的辅助细胞在胸腺中出现较早，但在脾脏中出现较晚。
During ontogeny, Ia-bearing accessory cells are found early in the thymus but late in the spleen.
作者信息
Lu C Y, Beller D I, Unanue E R
出版信息
Proc Natl Acad Sci U S A. 1980 Mar;77(3):1597-601. doi: 10.1073/pnas.77.3.1597.
Abstract
The ontogeny of Ia-bearing accessory cells was studied in mice. Ia-bearing adherent cells from the thymus, consisting predominantly of macrophages, were found from birth. These adherent cells were able to present antigen, as measured by their ability to induce immune T-cell proliferation. In contrast, Ia-bearing adherent cells from the spleen were not found until the second week of life, and their antigen-presentation function was not present until later. The differential ontogeny of Ia-bearing accessory cells at these sites may be important in both development of immune competence and the restriction of autoimmunity.
摘要
对小鼠中携带Ia的辅助细胞的个体发生进行了研究。从出生起就发现胸腺中携带Ia的贴壁细胞，主要由巨噬细胞组成。这些贴壁细胞能够呈递抗原，这通过它们诱导免疫T细胞增殖的能力来衡量。相比之下，脾脏中携带Ia的贴壁细胞直到出生后第二周才被发现，并且它们的抗原呈递功能直到更晚才出现。这些部位携带Ia的辅助细胞的个体发生差异在免疫能力的发展和自身免疫的限制中可能都很重要。
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During ontogeny, Ia-bearing accessory cells are found early in the thymus but late in the spleen.在个体发育过程中，携带Ia的辅助细胞在胸腺中出现较早，但在脾脏中出现较晚。
Proc Natl Acad Sci U S A. 1980 Mar;77(3):1597-601. doi: 10.1073/pnas.77.3.1597.
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本文引用的文献
1
IA antigens and antigen-presenting function of thymic macrophages.IA抗原与胸腺巨噬细胞的抗原呈递功能。
J Immunol. 1980 Mar;124(3):1433-40.
2
3
Isogeneic lymphocyte interaction: recognition of self antigens by cells of the neonatal thymus.同基因淋巴细胞相互作用：新生胸腺细胞对自身抗原的识别。
Proc Natl Acad Sci U S A. 1970 Oct;67(2):613-9. doi: 10.1073/pnas.67.2.613.
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Normal development of the thymus-dependent limb of humoral immune responses in mice.小鼠体液免疫反应中胸腺依赖部分的正常发育。
Eur J Immunol. 1973 Aug;3(8):506-11. doi: 10.1002/eji.1830030811.
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Function of macrophages in antigen recognition by guinea pig T lymphocytes. II. Role of the macrophage in the regulation of genetic control of the immune response.豚鼠T淋巴细胞抗原识别中巨噬细胞的功能。II. 巨噬细胞在免疫反应基因控制调节中的作用。
J Exp Med. 1973 Nov 1;138(5):1213-29. doi: 10.1084/jem.138.5.1213.
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Evidence for a blood-thymus barrier using electron-opaque tracers.使用电子不透明示踪剂证明血胸腺屏障的存在。
J Exp Med. 1972 Sep 1;136(3):466-98. doi: 10.1084/jem.136.3.466.
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Secretion of mediators following T lymphocyte-macrophage interaction is regulated by the major histocompatibility complex.T淋巴细胞与巨噬细胞相互作用后介质的分泌受主要组织相容性复合体调控。
Proc Natl Acad Sci U S A. 1977 Aug;74(8):3542-6. doi: 10.1073/pnas.74.8.3542.
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