甲状腺激素对大鼠脑发育过程中3-氧代酸辅酶A转移酶活性的影响。
Effect of thyroid hormones on the 3-oxo acid CoA-transferase activity in rat brain during development.
作者信息
Diez-Guerra J, Aragón M C, Giménez C, Valdivieso F
出版信息
Enzyme. 1980;25(2):106-10. doi: 10.1159/000459228.
PMID:6929751
Abstract
The changes in the developmental pattern of 3-oxo acid CoA-transferase activity in the brain of hypothyroid rats and the effect of triiodothyronine on this enzyme activity have been investigated. Hypothyroid rats showed lower activity than controls during the suckling period. However, higher enzyme levels were found in treated rats after weaning in contrast to control animals. The results suggest that thyroid hormones promote the development of enzymes of ketone-body metabolism in the brain.
摘要
研究了甲状腺功能减退大鼠大脑中3-氧代酸辅酶A转移酶活性发育模式的变化以及三碘甲状腺原氨酸对该酶活性的影响。甲状腺功能减退大鼠在哺乳期的活性低于对照组。然而，与对照动物相比，断奶后治疗组大鼠的酶水平较高。结果表明，甲状腺激素促进大脑中酮体代谢酶的发育。
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