Cedergren R J, LaRue B, Sankoff D, Lapalme G, Grosjean H
Proc Natl Acad Sci U S A. 1980 May;77(5):2791-5. doi: 10.1073/pnas.77.5.2791.
The convergence of ancestral sequences independently constructed from different branches of a phylogenetic tree can be used as a test of homology of data sequences. This criterion has shown that all phenylalanine tRNAs are related to a common ancestor, whereas eukaryotic and prokaryotic tyrosine tRNAs may have independent origins. All glycine tRNAs share a common ancestor. The glycine tRNA family splits according to the purine or pyrimidine nature of the first anticodon base prior to the divergence of eukaryotes and prokaryotes. The structural similarity between some prokaryotic glycine and and valine tRNAs is the result of their derivation from a common ancestor that existed previous to the divergence of the different glycine tRNAs. These results support models of genetic code evolution involving the incremental elaboration of earlier, simpler codes.
从系统发育树的不同分支独立构建的祖先序列的趋同可用于检验数据序列的同源性。这一标准表明,所有苯丙氨酸tRNA都与一个共同祖先相关,而真核生物和原核生物的酪氨酸tRNA可能有独立的起源。所有甘氨酸tRNA都有一个共同祖先。在真核生物和原核生物分化之前,甘氨酸tRNA家族根据第一个反密码子碱基的嘌呤或嘧啶性质而分开。一些原核生物甘氨酸tRNA和缬氨酸tRNA之间的结构相似性是它们源自不同甘氨酸tRNA分化之前存在的共同祖先的结果。这些结果支持了涉及早期、更简单密码子逐步细化的遗传密码进化模型。