一种存在于比奇地松鼠体内、与人类乙肝病毒相关的病毒。
A virus in Beechey ground squirrels that is related to hepatitis B virus of humans.
作者信息
Marion P L, Oshiro L S, Regnery D C, Scullard G H, Robinson W S
出版信息
Proc Natl Acad Sci U S A. 1980 May;77(5):2941-5. doi: 10.1073/pnas.77.5.2941.
A virus given the name ground squirrel hepatitis virus (or GSHV), with many of the unique characteristics of human hepatitis B virus (HBV), has been found in Beechey ground squirrels in northern California. Common features include virus morphology, viral DNA size and structure, a virion DNA polymerase that repairs a single-stranded region in the viral DNA, crossreacting viral antigens, and persistent infection with viral antigen continuously in the blood. Although similar, GSHV and HBV Are not identical. The ground squirrel virion has a slightly greater diameter, the viral surface antigens crossreact only partially and, thus, are not identical, and GSHV DNA has two restriction endonuclease EcoRI cleavage sites in contrast to the single site in HBV DNA. Thus, GSHV is a member of the virus group that includes HBV and the virus recently found in woodchucks in the eastern United States and named woodchuck hepatitis virus. It is not yet known how closely the ground squirrel and woodchuck viruses are related.
在加利福尼亚州北部的比奇地松鼠体内发现了一种名为地松鼠肝炎病毒（GSHV）的病毒，它具有人类乙型肝炎病毒（HBV）的许多独特特征。共同特征包括病毒形态、病毒DNA大小和结构、修复病毒DNA中单链区域的病毒粒子DNA聚合酶、交叉反应的病毒抗原以及血液中持续存在病毒抗原的持续性感染。尽管GSHV和HBV相似，但并不完全相同。地松鼠病毒粒子的直径略大一些，病毒表面抗原只是部分交叉反应，因此并不相同，并且与HBV DNA中的单个位点相比，GSHV DNA有两个限制性内切酶EcoRI切割位点。因此，GSHV是包括HBV以及最近在美国东部土拨鼠体内发现并命名为土拨鼠肝炎病毒的病毒组的成员。目前尚不清楚地松鼠病毒和土拨鼠病毒的亲缘关系有多近。
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