Hammond P
Department of Communication and Neurosciences,University of Keele, Keele, Staffordshire ST5 5BG Great Britain.
Pain. 1978 Aug;5(2):143-151. doi: 10.1016/0304-3959(78)90036-2.
Under carefully controlled conditions, nitrous oxide/oxygen mixtures alone, in concentrations up to 80% nitrous oxide, are shown to be unsuitable for maintaining anaesthesia during physiological recording in cats. An alternative technique is described, in which N2O/O2 (72.5% : 27.5%) is supplemented with minimal amounts of intravenous pentobarbitone (averaging 1 mg/kg/hr), following induction and surgical preparation under halothane. The technique is suitable for single unit recording from the CNS of cats in long-term acute experiments, especially those involving immobilisation with muscle relaxants. With appropriate antibiotic prophylaxis the technique is also suitable for shorter-term recording sessions in chronically implanted cats permitted to recover between sessions.
在严格控制的条件下，单独使用氧化亚氮/氧气混合物，其中氧化亚氮浓度高达80%，已被证明不适用于在猫进行生理记录期间维持麻醉。本文描述了一种替代技术，即在氟烷诱导和手术准备后，用微量静脉注射戊巴比妥（平均1mg/kg/小时）补充N2O/O2（72.5%:27.5%）。该技术适用于长期急性实验中从猫的中枢神经系统进行单单位记录，特别是那些涉及使用肌肉松弛剂进行固定的实验。通过适当的抗生素预防，该技术也适用于在慢性植入猫中进行的短期记录，允许在记录期间恢复。
