da Costa M, Isacoff W, Rothenberg S P, Iqbal M P
Cancer. 1980 Aug 1;46(3):471-4. doi: 10.1002/1097-0142(19800801)46:3<471::aid-cncr2820460309>3.0.co;2-o.
Three patients who were treated repetitive courses of high-dose methotrexate and leucovorin rescue experienced hypersensitivity symptoms infusion of the drug. Serum from all three patients contained one complex of methotrexate bound to a protein similar in size to albumin and a second complex of the protein-bound methotrexate coupled to IgG. This immune complex was not found in 4 patients similarly treated who did not experience hypersensitivity symptoms.
三名接受大剂量甲氨蝶呤和亚叶酸解救重复疗程治疗的患者在输注该药物时出现了过敏症状。所有三名患者的血清中都含有一种与白蛋白大小相似的蛋白质结合的甲氨蝶呤复合物，以及第二种与IgG偶联的蛋白质结合甲氨蝶呤复合物。在另外四名接受类似治疗但未出现过敏症状的患者中未发现这种免疫复合物。
