Waller C A, Gill P G, MacLennan I C
J Natl Cancer Inst. 1980 Aug;65(2):223-30.
Lymphocyte numbers and function in 37 patients with colorectal cancer were compared with those in 23 healthy controls of the same age range. No significant difference in lymphocyte count, numbers of cells forming erythrocyte rosettes or bearing surface immunoglobulin, cell-mediated cytotoxicity, or mitotic response to phytohemagglutinin (PHA) was found. Six to 12 months after tumor resection, patients showed a rise in spontaneous, antibody-induced, and PHA-induced cytotoxicities to levels significantly higher than those found in age-matched controls. This rise occurred irrespective of whether patients had received adjuvant immunotherapy with Corynebacterium parvum.
对37例结直肠癌患者的淋巴细胞数量和功能与23例年龄范围相同的健康对照者进行了比较。结果发现，淋巴细胞计数、形成红细胞玫瑰花结或带有表面免疫球蛋白的细胞数量、细胞介导的细胞毒性或对植物血凝素（PHA）的有丝分裂反应均无显著差异。肿瘤切除后6至12个月，患者的自发、抗体诱导和PHA诱导的细胞毒性均升高，达到显著高于年龄匹配对照者的水平。无论患者是否接受了短小棒状杆菌辅助免疫治疗，这种升高都会出现。
