Dryzhak V I, Iaremenko A V, Khramtsova N S
Vopr Onkol. 1989;35(5):585-9.
Blood level of large granular cells was assayed in patients suffering cancer of the breast (30), colon (13) and rectum (34) at various stages of the disease. This level in cancer patients was half as much that in healthy controls. Procedures employed for treatment of the above pathologies were shown to contribute to inhibition of peripheral blood spontaneous cytotoxicity. This makes the case for immunocorrection. The cytologic method of identification of large granular lymphocytes may be used to monitor cell-mediated antitumor immunity in breast and colorectal cancer patients in the course and after treatment and, therefore, serve the diagnosis of recurrence and metastasis.
对处于疾病不同阶段的乳腺癌患者（30例）、结肠癌患者（13例）和直肠癌患者（34例）的大颗粒细胞血水平进行了测定。癌症患者的这一水平是健康对照者的一半。已证明用于治疗上述病症的程序有助于抑制外周血自发细胞毒性。这为免疫纠正提供了依据。大颗粒淋巴细胞的细胞学鉴定方法可用于监测乳腺癌和结直肠癌患者在病程中和治疗后的细胞介导抗肿瘤免疫，因此可用于诊断复发和转移。
