Dencker S J, Malm U, Jørgensen A, Overø K F
Acta Psychiatr Scand Suppl. 1980;279:55-63. doi: 10.1111/j.1600-0447.1980.tb07083.x.
Two pharmacolkinetic parameters viz. the minimum serum concentration in the dosage interval and the sera under the serum concentration curve have been correlated to 14 parameters for clinical outcome, viz. total points and factor points from the three rating scales, BPRS, CPRS, and side effects scale, in a double blind clinical trial of clopenthixol and flupenthixol depot preparations in outpatient schizophrenics. No statistically significant correlations were observed. It is of some interest, however, that the results suggest that the treatment of individual patients with neurleptics may be adjusted by means of repeated ratings, residual percentage, changes in psychopathology, and determinations of serum concentrations. Our results do not indicate any optimal concentration range for these depot neuroleptics in the maintenance phase of schizophrenia. The so-called therapeutic window as to neuroleptics obviously varies with regard to the phase of the disease as well as the patients' social situation.
在一项针对门诊精神分裂症患者的氯哌噻吨和氟哌噻吨长效制剂的双盲临床试验中，两个药代动力学参数，即给药间隔期的最低血清浓度和血清浓度曲线下的血清浓度，已与14个临床结局参数相关联，这些参数包括来自三个评定量表（BPRS、CPRS和副作用量表）的总分和因子分。未观察到具有统计学意义的相关性。然而，有趣的是，结果表明，可以通过重复评定、残留百分比、精神病理学变化和血清浓度测定来调整个体患者的抗精神病药物治疗。我们的结果并未表明这些长效抗精神病药物在精神分裂症维持期的任何最佳浓度范围。所谓的抗精神病药物治疗窗显然因疾病阶段以及患者的社会状况而异。
