The anatomy of the human genome.

More than 350 genes have been assigned to specific chromosomes. These include more than 110 assigned to the X chromosome, more than 240 assigned to specific autosomes, and at least one assigned to the Y chromosome. (Even man's 25th chromosome, that of the mitochondrion, is being mapped). Almost all the assignments to specific autosomes were made in the last decade. About half of these were made by study of clones derived from interspecific (e.g., man-mouse) somatic cell hybrids. Over a fifth were made by family linkage studies. Chromosomes 1 and 6 are rather extensively mapped. The genes of over 40 autosomal disorders have been specifically localized. The comparative anatomy, functional anatomy, developmental anatomy and even applied anatomy of the human genome is becoming better known.