小鼠c-fes和c-src基因的染色体定位
Chromosomal mapping of murine c-fes and c-src genes.
作者信息
Blatt C, Harper M E, Franchini G, Nesbitt M N, Simon M I
出版信息
Mol Cell Biol. 1984 May;4(5):978-81. doi: 10.1128/mcb.4.5.978-981.1984.
The murine homologs of two viral oncogenes associated with tyrosine-specific kinase activity have been assigned to different loci in the mouse genome. The segregation of restriction site polymorphisms, as detected by probes that are specific for endogenous c-fes and c-src sequences, was followed in the DNA of recombinant inbred strains. The c-fes gene was mapped to the proximal portion of chromosome 7, very close to the Gpi-1 locus, whereas c-src was linked to the Psp locus on the distal half of chromosome 2.
与酪氨酸特异性激酶活性相关的两种病毒癌基因的小鼠同源基因已被定位到小鼠基因组的不同位点。通过对内源c-fes和c-src序列具有特异性的探针检测到的限制性位点多态性的分离，在重组近交系的DNA中进行了跟踪。c-fes基因被定位到7号染色体的近端部分，非常靠近Gpi-1位点，而c-src则与2号染色体远端一半的Psp位点相连。
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