使用门控31P核磁共振测量心动周期中高能磷酸盐的变化。
Measurement of changes in high-energy phosphates in the cardiac cycle using gated 31P nuclear magnetic renonance.
作者信息
Fossel E T, Morgan H E, Ingwall J S
出版信息
Proc Natl Acad Sci U S A. 1980 Jun;77(6):3654-8. doi: 10.1073/pnas.77.6.3654.
Abstract
Levels of the high-energy phosphate-containing compounds, ATP and creatine phosphate, and of inorganic phosphate (Pi) were measured as a function of position in the cardiac cycle. Measurements were made on isolated, perfused, working rat hearts through the use of gated 31P nuclear magnetic resonance spectroscopy. Levels of ATP and creatine phosphate were found to vary during the cardiac cycle and were maximal at minimal aortic pressure and minimal at maximal aortic pressure. Pi varied inversely with the high-energy phosphates.
摘要
对含高能磷酸化合物、三磷酸腺苷（ATP）和磷酸肌酸以及无机磷酸（Pi）的水平，作为心动周期中位置的函数进行了测量。通过使用门控31P核磁共振波谱法，对离体、灌注、工作的大鼠心脏进行了测量。发现ATP和磷酸肌酸的水平在心动周期中有所变化，在主动脉压力最低时最高，在主动脉压力最高时最低。Pi与高能磷酸盐呈相反变化。
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