Bottomley P A, Hardy C J, Roemer P B
GE Corporate Research and Development Center, Schenectady, New York 12301.
Magn Reson Med. 1990 Jun;14(3):425-34. doi: 10.1002/mrm.1910140302.
Cardiac-gated phosphorus (31P) nuclear magnetic resonance (NMR) spectroscopic imaging with surface coils resolves in three dimensions the spatial distribution of high energy phosphate metabolites in the human heart noninvasively. 31P spectra derive from 6- to 14-cm3 volumes of myocardium in the anterior left ventricle, septum, and apex, at depths of up to about 8 cm from the chest, as identified by proton (1H) NMR anatomical images acquired without moving the subject. Spectroscopic images are acquired in 9 to 21 min at 1.5 T. Metabolite concentrations are quantified with reference to a standard located outside the chest, yielding normal in vivo concentrations of phosphocreatine and adenosine triphosphate of about 11.0 +/- 2.7 (SD) and 6.9 +/- 1.6 mumol/g of wet heart tissue, respectively. High energy phosphate contents did not vary significantly with location in the normal myocardium, but 2,3-diphosphoglycerate signals from blood varied with subject and location.
采用表面线圈的心脏门控磷（31P）核磁共振（NMR）波谱成像能够在三维空间无创解析人体心脏中高能磷酸代谢物的空间分布。31P波谱源自左心室前壁、室间隔和心尖处6至14立方厘米的心肌组织，深度可达距胸部约8厘米，这是通过在不移动受试者的情况下采集的质子（1H）NMR解剖图像确定的。在1.5T磁场下，9至21分钟内采集波谱图像。代谢物浓度通过参考置于胸部外的标准物进行定量，得出磷酸肌酸和三磷酸腺苷在活体中的正常浓度分别约为11.0±2.7（标准差）和6.9±1.6微摩尔/克湿心脏组织。在正常心肌中，高能磷酸含量在不同位置并无显著差异，但血液中的2,3-二磷酸甘油酸信号因受试者和位置而异。
