Budtz-Jørgensen E
Scand J Dent Res. 1980 Jun;88(3):171-80. doi: 10.1111/j.1600-0722.1980.tb01211.x.
A dysfunctional occlusal relationship was produced in six Macaca irus monkeys by insertion of occlusal splints in the maxilla which raised the vertical dimension of occlusion by 3-4 mm and incorporated interferences into the occlusion (test side). Cortisol levels of plasma and urine were measured by competitive protein binding analysis. At week 1 and week 3 after insertion of the splints there was a significant increase of 24 h urinary cortisol excretion rate and plasma cortisol concentration, indicating emotional stress. Furthermore, there was evidence of acute trauma from occlusion of the mandibular teeth of the test side, including a significant increase of tooth mobility and GI; radiographically there were signs of breakdown of margial and interradicular alveolar bone. One animal developed periodontal pockets of 4-5 mm adjacent to the teeth of the test side. At week 6 and week 12 urinary and plasma cortisol levels had declined to basal values whereas tooth mobility, GI and PI remained elevated. There was no clinical or radiographic evidence of further loss of bone or increase of pocket depth adjacent to the teeth of the test side during the latter part of the experimental period. The results suggest that emotional stress may be involved in periodontal reactions associated with acute trauma from occlusion.
通过在上颌植入咬合夹板，使六只食蟹猴建立功能失调的咬合关系，该夹板使咬合垂直距离增加3 - 4毫米，并在咬合中引入干扰（试验侧）。通过竞争性蛋白结合分析法测量血浆和尿液中的皮质醇水平。在插入夹板后的第1周和第3周，24小时尿皮质醇排泄率和血浆皮质醇浓度显著增加，表明存在情绪应激。此外，有证据表明试验侧下颌牙存在咬合急性创伤，包括牙齿松动度和牙龈指数显著增加；影像学上有边缘和根间牙槽骨破坏的迹象。一只动物在试验侧牙齿相邻处出现了4 - 5毫米深的牙周袋。在第6周和第12周，尿和血浆皮质醇水平已降至基础值，而牙齿松动度、牙龈指数和牙周指数仍升高。在实验后期，试验侧牙齿相邻处没有进一步骨丧失或牙周袋深度增加的临床或影像学证据。结果表明，情绪应激可能参与了与咬合急性创伤相关的牙周反应。
