Budtz-Jørgensen E
J Oral Rehabil. 1981 Jan;8(1):1-9. doi: 10.1111/j.1365-2842.1981.tb00469.x.
A dysfunctional occlusal relationship was produced in six macaca irus monkeys by insertion of occlusal splints which raised the vertical dimension of occlusion by 3--4 mm and incorporated interferences into the occlusion. Cortisol levels of plasma and 24 h urine samples were measured by competitive protein-binding analysis. After insertion of the splints there was an immediate, approximately two-fold rise of the mean 24 h urinary cortisol excretion rate and a significant decrease of urinary volume and body weight. The plasma cortisol level did not rise significantly. During the 3 weeks experimental period the teeth showed increasing mobility and occlusal wear facets developed on the splints. Urinary cortisol excretion rates were significantly elevated throughout the experimental period. Urinary cortisol levels declined to basal values when the splints were removed. This animal model produces experimental evidence in support of the hypothesis that a dysfunctional occlusal relationship may result in bruxism associated with emotional stress.
通过插入咬合夹板在6只猕猴中建立了功能失调的咬合关系，这些夹板使咬合垂直距离增加了3 - 4毫米，并在咬合中引入了干扰。通过竞争性蛋白结合分析测量血浆和24小时尿液样本中的皮质醇水平。插入夹板后，24小时尿皮质醇排泄率平均立即升高约两倍，尿量和体重显著下降。血浆皮质醇水平没有显著升高。在3周的实验期内，牙齿的松动度增加，夹板上出现了咬合磨损面。在整个实验期内，尿皮质醇排泄率显著升高。去除夹板后，尿皮质醇水平降至基础值。该动物模型提供了实验证据，支持功能失调的咬合关系可能导致与情绪压力相关的磨牙症这一假说。
