Kobayashi T K, Yuasa M, Fujimoto T, Fukuda M, Harami K, Hayashi K
Acta Cytol. 1980 Jul-Aug;24(4):328-34.
A study was undertaken to evaluate the cytologic features of pregnancy-induced cell patterns (PIP) observed in postpartum and postabortal cervicovaginal smears. A total of 3,000 PIP were evaluated and studied by an indirect immunofluorescent technique using human chorionic gonadotropin (HCG). Three characteristic types of PIP were demonstrated. In type I PIP, the cells had a sheetlike arrangement with a fine chromatin pattern and were thought to be of decidual origin. Type II PIP were shed in clumps and had round nuclei, cytoplasmic vacuoles and coarse chromatin. They were thought to originate in the endometrium with the Arias-Stella reaction. Type III PIP were large and had large nuclei with marked atypism. They were thought to be cytotrophoblasts. Almost all of the type III PIP were positive with the anti-HCG stain. It is concluded that this classification and analysis is significant and could reduce the number of false-positive cytology reports on postpartum and postabortal smears.
一项研究旨在评估产后和流产后宫颈阴道涂片所见妊娠诱导细胞模式（PIP）的细胞学特征。使用人绒毛膜促性腺激素（HCG），通过间接免疫荧光技术对总共3000个PIP进行了评估和研究。证实了三种特征性的PIP类型。在I型PIP中，细胞呈片状排列，染色质模式细腻，被认为起源于蜕膜。II型PIP成簇脱落，细胞核圆形，有细胞质空泡和粗糙的染色质。它们被认为起源于子宫内膜并伴有阿rias-Stella反应。III型PIP较大，细胞核大，有明显异型性。它们被认为是细胞滋养层细胞。几乎所有III型PIP抗HCG染色呈阳性。结论是，这种分类和分析具有重要意义，可减少产后和流产后涂片细胞学假阳性报告的数量。
