Stanbridge D M, Butler E B, Langley F A
Acta Cytol. 1980 Jul-Aug;24(4):335-43.
The ultrastructure of cytologically abnormal, thick cell groups and epithelial fragments in cervical and vaginal scrape material was investigated and found to be useful in differentiating between carcinoma in situ, invasive nonkeratinizing squamous carcinoma and adenocarcinoma of the endocervix and also in confirming the presence of cytologically suspected vault deposits of recurrent endometrial adenocarcinoma. It was demonstrated that although accurate evaluation of these thick groups in smear preparations is often not possible, thick sections of similar, plastic-embedded material showed some features which enabled a distinction to be made between squamous and glandular lesions and that these differences were more pronounced at the ultrastructural level. The squamous lesions were characterized by wide intercellular spaces with microvilli and tonofibrils within the cytoplasm while glandular lesions showed narrow intercellular spaces, prominent Golgi zones and endoplasmic reticulum together with mucus droplets in some cells.
对宫颈和阴道刮片材料中细胞学异常的厚细胞群及上皮碎片的超微结构进行了研究，发现其有助于鉴别宫颈原位癌、浸润性非角化鳞状细胞癌及宫颈腺癌，也有助于证实细胞学怀疑的复发性子宫内膜腺癌穹窿部沉积物的存在。结果表明，虽然在涂片制备中对这些厚细胞群进行准确评估往往是不可能的，但类似的塑料包埋材料的厚切片显示出一些特征，能够区分鳞状和腺性病变，且这些差异在超微结构水平上更为明显。鳞状病变的特征是细胞间隙宽，细胞质内有微绒毛和张力原纤维，而腺性病变则显示细胞间隙窄、高尔基体区和内质网突出，部分细胞内还有黏液滴。
