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宫颈和阴道刮片材料中乳头瘤病毒颗粒的显示：10例报告。

Demonstration of papilloma virus particles in cervical and vaginal scrape material: a report of 10 cases.

作者信息

Stanbridge C M, Mather J, Curry A, Butler E B

出版信息

J Clin Pathol. 1981 May;34(5):524-31. doi: 10.1136/jcp.34.5.524.

DOI:10.1136/jcp.34.5.524
PMID:6265502
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC493337/
Abstract

The finding of virus particles by transmission electron microscopy (TEM) in fixed cervical and vaginal scrape material and their identification as papilloma viruses by negative staining is described. The colposcopic, cytological, and histological appearances in a group of 10 patients in whom virus particles were seen are discussed and the possibly considered of an association between papilloma virus infection and the development of cervical intraepithelial neoplasia (CIN) and multifocal intraepithelial neoplasia of the female lower genital tract.

摘要

本文描述了通过透射电子显微镜（TEM）在固定的宫颈和阴道刮片材料中发现病毒颗粒，并通过负染色将其鉴定为人乳头瘤病毒。讨论了在一组10例可见病毒颗粒的患者中的阴道镜、细胞学和组织学表现，并探讨了人乳头瘤病毒感染与宫颈上皮内瘤变（CIN）以及女性下生殖道多灶性上皮内瘤变发展之间可能存在的关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45e2/493337/80e7ebad7ae1/jclinpath00486-0075-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45e2/493337/27dd3f91af35/jclinpath00486-0071-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45e2/493337/a2e0840da18d/jclinpath00486-0071-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45e2/493337/5655caa51120/jclinpath00486-0072-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45e2/493337/26bdc13dadf8/jclinpath00486-0072-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45e2/493337/54fc56adf114/jclinpath00486-0074-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45e2/493337/2ddb5622f548/jclinpath00486-0074-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45e2/493337/80e7ebad7ae1/jclinpath00486-0075-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45e2/493337/27dd3f91af35/jclinpath00486-0071-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45e2/493337/a2e0840da18d/jclinpath00486-0071-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45e2/493337/5655caa51120/jclinpath00486-0072-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45e2/493337/26bdc13dadf8/jclinpath00486-0072-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45e2/493337/54fc56adf114/jclinpath00486-0074-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45e2/493337/2ddb5622f548/jclinpath00486-0074-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45e2/493337/80e7ebad7ae1/jclinpath00486-0075-a.jpg

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Demonstration of papilloma virus particles in cervical and vaginal scrape material: a report of 10 cases.宫颈和阴道刮片材料中乳头瘤病毒颗粒的显示：10例报告。
J Clin Pathol. 1981 May;34(5):524-31. doi: 10.1136/jcp.34.5.524.
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[Cell patterns induced by human papilloma virus in samples sent to a cytodiagnostic central laboratory].[送往细胞诊断中心实验室的样本中人类乳头瘤病毒诱导的细胞模式]
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引用本文的文献

1
Cervical intraepithelial neoplasia.宫颈上皮内瘤变
J Clin Pathol. 1982 Jan;35(1):1-13. doi: 10.1136/jcp.35.1.1.
2
Human cancers and human viruses.人类癌症与人类病毒。
Br Med J (Clin Res Ed). 1982 Feb 13;284(6314):446-8. doi: 10.1136/bmj.284.6314.446.
3
Human papillomaviruses: are we ready to type?人乳头瘤病毒：我们准备好分型了吗？

本文引用的文献

1
Electron microscope study of human warts; sites of virus production and nature of the inclusion bodies.人类疣的电子显微镜研究；病毒产生部位及包涵体的性质。
J Invest Dermatol. 1962 Jun;38:337-45.
2
Carcinoma in situ of the vulva.外阴原位癌
Obstet Gynecol. 1980 Feb;55(2):225-30.
3
Problems in cervicovaginal cytology: fine structure as an aid to diagnosis.宫颈阴道细胞学的问题：作为诊断辅助手段的精细结构
Clin Microbiol Rev. 1989 Apr;2(2):166-90. doi: 10.1128/CMR.2.2.166.
4
Sensitivity of digoxigenin and biotin labelled probes for detection of human papillomavirus by in situ hybridisation.地高辛配基和生物素标记探针通过原位杂交检测人乳头瘤病毒的敏感性。
J Clin Pathol. 1990 Oct;43(10):800-5. doi: 10.1136/jcp.43.10.800.
5
A research for the relationship between human papillomavirus and human uterine cervical carcinoma. II. Molecular genetic and ultrastructural study on the transforming activity of recombinant retrovirus containing human papillomavirus type 16 subgenomic sequences.人乳头瘤病毒与人类子宫颈癌关系的研究。II. 含人乳头瘤病毒16型亚基因组序列重组逆转录病毒转化活性的分子遗传学及超微结构研究。
J Cancer Res Clin Oncol. 1991;117(5):460-72. doi: 10.1007/BF01612768.
Acta Cytol. 1980 Jul-Aug;24(4):335-43.
4
Immunologic identification of papillomavirus antigen in condyloma tissues from the female genital tract.女性生殖道尖锐湿疣组织中乳头瘤病毒抗原的免疫学鉴定
Obstet Gynecol. 1980 Dec;56(6):727-32.
5
Multicentric squamous cell carcinomas of the lower female genital tract. Eleven cases with epidermoid carcinoma of both vulva and cervix.女性下生殖道多中心鳞状细胞癌。11例同时患有外阴和宫颈表皮样癌。
Am J Obstet Gynecol. 1967 Aug 1;98(7):982-6. doi: 10.1016/0002-9378(67)90085-3.
6
Squamous cell carcinoma of the vulva.外阴鳞状细胞癌
Obstet Gynecol. 1966 Nov;28(5):670-4.
7
Correlated investigative technics of multiple anaplasias in the lower genital canal.下生殖道多形性肿瘤的相关调查技术
Obstet Gynecol. 1969 May;33(5):609-16.
8
Epidemiology of epidermoid carcinoma of the vulva.外阴表皮样癌的流行病学
Obstet Gynecol. 1972 Feb;39(2):165-72.
9
Demonstration of virus particles in human genital warts.人类生殖器疣中病毒颗粒的显示。
Br J Vener Dis. 1970 Feb;46(1):37-42. doi: 10.1136/sti.46.1.37.
10
Condylomatous lesions of the cervix and vagina. I. Cytologic patterns.宫颈和阴道的湿疣病变。I. 细胞学模式。
Acta Cytol. 1976 Nov-Dec;20(6):505-9.