Albrecht E
Acta Endocrinol (Copenh). 1980 Jun;94(2):242-5. doi: 10.1530/acta.0.0940242.
Polycystic ovaries were induced in thyroidectomized rabbits by the administration of either 25 IU human chorionic gonadotrophin or 10 IU pregnant mare serum daily for a period of 20 days. Cystic ovaries in rabbits exhibited subnormal (P < 0.01) ovarian delta 5-3 beta-hydroxysteroid dehydrogenase (3 beta-HSD) concentration and specific activity. Since weight of cystic ovaries was markedly elevated, however, total capacity for delta 4-3-ketosteroid production was enhanced. Concomitant administration of chorionic gonadotrophin and aminoglutethimide phosphate to thyroidectomized rabbits prevented the formation of cystic ovaries indicating that a steroid, or steroids formed beyond cholesterol in the biosynthesis pathway is necessary for the experimental induction of cystic ovaries in this laboratory animal.
通过每天给甲状腺切除的兔子注射25国际单位人绒毛膜促性腺激素或10国际单位孕马血清，持续20天，诱导其产生多囊卵巢。兔子的囊性卵巢表现出低于正常水平（P<0.01）的卵巢δ5-3β-羟基类固醇脱氢酶（3β-HSD）浓度和比活性。然而，由于囊性卵巢的重量显著增加，因此δ4-3-酮类固醇的总生成能力增强。向甲状腺切除的兔子同时给予绒毛膜促性腺激素和磷酸氨鲁米特可防止囊性卵巢的形成，这表明在生物合成途径中，一种或多种在胆固醇之后形成的类固醇对于在这种实验动物中实验性诱导囊性卵巢是必需的。
