Altman E G
Aust Dent J. 1980 Jun;25(3):135-8. doi: 10.1111/j.1834-7819.1980.tb03702.x.
Metronidazole is the drug of choice in the chemotherapy of necrotizing ulcerative gingivitis. It is also used in high dosage in the chemoprophylaxis and treatment of many strictly anaerobic infections. Prolonged use has been advocated in the treatment of periodonititis. Attention is drawn to known drug interactions, toxic effects, and the possibility of development of resistant strains.
甲硝唑是坏死性溃疡性牙龈炎化疗的首选药物。它也被高剂量用于多种严格厌氧菌感染的化学预防和治疗。在牙周炎治疗中一直主张延长用药时间。要注意已知的药物相互作用、毒性作用以及耐药菌株产生的可能性。