Oral Health Prev Dent. 2024 Mar 14;22:139-144. doi: 10.3290/j.ohpd.b5081283.
To examine the clinical efficacy of a chlorhexidine gargle combined with recombinant bovine basic fibroblast growth factor (rb-bFGF) gel in the treatment of recurrent oral ulcers and its effects on inflammatory factors, immune function, and recurrence rate.
Ninety-six patients with recurrent oral ulcers were randomly assigned to two groups: experimental (treatment with chlorhexidine gargle plus rb-bFGF gel) and control (treatment with chlorhexidine gargle alone) (n = 48 cases). The therapeutic efficacy, clinical improvement of symptoms, and recurrence rate within 3 months were compared between the two groups. Serum inflammatory factor and immune factor levels of patients in the two groups were measured before and after treatment.
A statistically significantly higher total effective rate was found in patients of the experimental group (95.83%) versus the control group (81.25%) (p < 0.05). The time to onset of pain relief was shortened, the duration of pain relief was prolonged, and VAS scores for pain level were lower in the experimental than the control group (p < 0.05). Among patients in the experimental group, the number of oral ulcers and ulcer area decreased, and faster onset of pain relief and time until normal eating improved in comparison to the control group (p < 0.05). Reduced levels of IL-2, IL-6, IL-8, and TNF-α were observed in the experimental vs the control group (p < 0.05). Elevated levels of CD3+, CD4+, and NKT and reduced levels of CD8+ were found in the experimental group compared to the control group (p < 0.05). The ulcer recurrence rate of patients in the experimental group (8.33%) was notably lower in comparison to the control group (29.17%).
Chlorhexidine gargle plus rb-bFGF gel can improve the clinical outcome of patients with recurrent oral ulcers. It can reduce the levels of inflammatory factors, improve immune function, and reduce the recurrence rate.
观察洗必泰含漱液联合重组牛碱性成纤维细胞生长因子（rb-bFGF）凝胶治疗复发性口腔溃疡的临床疗效及其对炎症因子、免疫功能和复发率的影响。
将 96 例复发性口腔溃疡患者随机分为两组：实验组（洗必泰含漱液联合 rb-bFGF 凝胶治疗）和对照组（洗必泰含漱液治疗）（每组 48 例）。比较两组患者的治疗效果、症状改善情况和 3 个月内的复发率。检测两组患者治疗前后血清炎症因子和免疫因子水平。
实验组总有效率（95.83%）明显高于对照组（81.25%）（p＜0.05）。实验组患者疼痛缓解开始时间缩短，疼痛缓解持续时间延长，疼痛水平 VAS 评分低于对照组（p＜0.05）。实验组患者口腔溃疡数量和溃疡面积减少，疼痛缓解开始时间和正常进食时间均优于对照组（p＜0.05）。实验组患者 IL-2、IL-6、IL-8 和 TNF-α水平降低（p＜0.05）。实验组患者 CD3+、CD4+和 NKT 水平升高，CD8+水平降低（p＜0.05）。实验组患者溃疡复发率（8.33%）明显低于对照组（29.17%）。
洗必泰含漱液联合 rb-bFGF 凝胶可提高复发性口腔溃疡患者的临床疗效。它可以降低炎症因子水平，改善免疫功能，降低复发率。
