Mao M W, Rosen S
J Dent Res. 1980 Oct;59(10):1620-6. doi: 10.1177/00220345800590101101.
In this study, we induced a number of mutants of S. mutans differing in their abilities to synthesize glucan and produce acid. When tested for cariogenicity in gnotobiotic rats, "high pH" mutants caused less caries, but could not supplant a cariogenic parent strain.
在本研究中,我们诱导出了一些变形链球菌突变体,它们在合成葡聚糖和产酸能力方面存在差异。在无菌大鼠中测试其致龋性时,“高pH值”突变体导致的龋齿较少,但无法取代致龋亲代菌株。