Hamada S, Koga T, Ooshima T
J Dent Res. 1984 Mar;63(3):407-11. doi: 10.1177/00220345840630031001.
Streptococcus mutans possesses the abilities to adhere to pellicle-coated tooth surfaces and to form acids - two characteristics associated with the cariogenicity of this micro-organism. De novo synthesis of insoluble glucan by S. mutans glucosyltransferase from sucrose is essential in the adherence process. Therefore, agents which interfere with the adherence ability of S. mutans would be useful for controlling dental caries. In the present report, we have summarized our recent findings concerning virulence factors of S. mutans and means for prevention of S. mutans-induced dental caries.
变形链球菌具有黏附于覆盖有获得性膜的牙齿表面以及产酸的能力——这两个特征与该微生物的致龋性相关。变形链球菌葡糖基转移酶从蔗糖中从头合成不溶性葡聚糖在黏附过程中至关重要。因此，干扰变形链球菌黏附能力的药物将有助于控制龋齿。在本报告中，我们总结了我们最近关于变形链球菌毒力因子以及预防变形链球菌所致龋齿方法的研究结果。
