O'Quinn A N, Thompson R J
Pediatrics. 1980 Sep;66(3):420-4.
Tourette's syndrome is a disorder of central nervous system functioning in which the most easily recognized symptoms of involuntary movements and vocalizations have been found to be responsive, in many cases, to pharmacotherapy with haloperidol. We have recently evaluated five patients with Tourette's syndrome and have been impressed with the learning difficulties, speech and language problems, and behavioral problems which accompanied the involuntary neuromotor manifestations. These lesser known manifestations were not improved with haloperidol, and in fact, the sleepiness associated with the use of haloperidol was thought to adversely affect school performance in two of our patients. Thus, a holistic approach to the evaluation and treatment of children with Tourette's syndrome is recommended. Early attention to possible speech and language difficulties, appropriate academic help, and counseling regarding behavior management are seen as management issues at least as important as medication management.
抽动秽语综合征是一种中枢神经系统功能紊乱疾病,其中最容易识别的不自主运动和发声症状在许多情况下已被发现对氟哌啶醇药物治疗有反应。我们最近评估了5例抽动秽语综合征患者,对伴随不自主神经运动表现出现的学习困难、言语和语言问题以及行为问题印象深刻。这些鲜为人知的表现并未因氟哌啶醇而改善,事实上,我们有两名患者使用氟哌啶醇后出现的嗜睡被认为对学业成绩有不利影响。因此,建议对抽动秽语综合征患儿采用整体评估和治疗方法。早期关注可能存在的言语和语言困难、提供适当的学业帮助以及进行行为管理咨询,这些管理问题至少与药物管理同样重要。