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抑郁症中的刺激强度控制:多塞平和阿米替林对皮质诱发电位比较效应的研究

Stimulus intensity control in depression: a study of the comparative effect of doxepin and amitriptyline on cortical evoked potentials.

作者信息

Friedman J, McCallum P, Meares R

出版信息

Aust N Z J Psychiatry. 1980 Jun;14(2):115-9. doi: 10.3109/00048678009159365.

DOI:10.3109/00048678009159365
PMID:6932866
Abstract

The perceived intensity of a stimulus may be magnified during depression. Stimulus intensity control can be studied by means of cortical evoked potentials. In a study of 33 depressives, cortical evoked potentials were greater during depression than on recovery. The effect of doxepin on the amplitudes of evoked potentials of depressives was compared with that of amitriptyline. Doxepin reduced amplitudes. Amitriptyline had a similar, but non-significant effect.

摘要

在抑郁期间,刺激的感知强度可能会被放大。刺激强度控制可以通过皮层诱发电位来研究。在一项对33名抑郁症患者的研究中,抑郁期间的皮层诱发电位比康复时更大。将多塞平对抑郁症患者诱发电位振幅的影响与阿米替林的影响进行了比较。多塞平降低了振幅。阿米替林有类似但不显著的效果。

相似文献

1
Stimulus intensity control in depression: a study of the comparative effect of doxepin and amitriptyline on cortical evoked potentials.抑郁症中的刺激强度控制:多塞平和阿米替林对皮质诱发电位比较效应的研究
Aust N Z J Psychiatry. 1980 Jun;14(2):115-9. doi: 10.3109/00048678009159365.
2
Amitriptyline-perphenazine and doxepin in depressed outpatients: a controlled double-blind study.阿米替林-奋乃静与多塞平治疗门诊抑郁症患者:一项对照双盲研究。
J Clin Psychiatry. 1982 Oct;43(10):419-22.
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Is amitriptyline + perphenazine superior to doxepin?
J Clin Psychiatry. 1983 May;44(5):195.
4
Low serum levels of tricyclic antidepressants in amitriptyline- and doxepin-treated inpatients with depressive syndromes are associated with nonresponse.在接受阿米替林和多塞平治疗的伴有抑郁综合征的住院患者中,三环类抗抑郁药血清水平低与治疗无反应相关。
Pharmacopsychiatry. 1996 May;29(3):97-102. doi: 10.1055/s-2007-979552.
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Ventricular arrhythmias induced by doxepin and amitriptyline: case report.多塞平和阿米替林诱发的室性心律失常:病例报告
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Amitriptyline versus placebo for major depressive disorder.阿米替林与安慰剂治疗重度抑郁症的比较。
Cochrane Database Syst Rev. 2012 Dec 12;12(12):CD009138. doi: 10.1002/14651858.CD009138.pub2.