原位给药
In situ drug delivery.
作者信息
Levin V A, Wright D C, Landahl H D, Patlak C S, Csejtey J
出版信息
Br J Cancer Suppl. 1980 Apr;4:74-8.
Abstract
Drug delivery to tumours and the accessibility of tumour cells to drugs remains a problem of foremost importance and is affected by many factors. We will discuss models we have developed for drug delivery from tumour capillaries to tumour cells, and drug delivery from well perfused, well oxygenated tumour regions to less well perfused hypoxic regions in terms of computer simulation of drug delivery for the anticancer agent BCNU and the hypoxic cell radiosensitizer misonidazole.
摘要
药物输送到肿瘤以及肿瘤细胞对药物的可及性仍然是一个至关重要的问题，并且受到许多因素的影响。我们将从计算机模拟抗癌药物卡莫司汀（BCNU）和乏氧细胞放射增敏剂米索硝唑的药物输送角度，讨论我们开发的从肿瘤毛细血管向肿瘤细胞输送药物以及从灌注良好、氧合良好的肿瘤区域向灌注较差的缺氧区域输送药物的模型。
相似文献
1
In situ drug delivery.原位给药
Br J Cancer Suppl. 1980 Apr;4:74-8.
2
Distribution and tumour cytotoxicity of the radiosensitizer misonidazole (Ro-07-0582) in C57 mice.放射增敏剂米索硝唑（Ro-07-0582）在C57小鼠体内的分布及肿瘤细胞毒性
Br J Cancer. 1979 Apr;39(4):429-33. doi: 10.1038/bjc.1979.76.
3
Pharmacokinetic considerations in testing hypoxic cell radiosensitizers in mouse tumours.在小鼠肿瘤中测试乏氧细胞放射增敏剂时的药代动力学考量
Br J Cancer. 1979 Mar;39(3):310-20. doi: 10.1038/bjc.1979.55.
4
The labelling of EMT-6 tumours in BALB/C mice with 14C-misonidazole.用¹⁴C-米索硝唑对BALB/C小鼠的EMT-6肿瘤进行标记。
Br J Radiol. 1983 Oct;56(670):745-53. doi: 10.1259/0007-1285-56-670-745.
5
In vitro potentiation of BCNU activity in rat brain tumour cells pretreated with misonidazole.用米索硝唑预处理的大鼠脑肿瘤细胞中卡莫司汀活性的体外增强作用。
Br J Cancer. 1984 Jun;49(6):795-9. doi: 10.1038/bjc.1984.123.
6
Binding of 14C-misonidazole to hypoxic cells in V79 spheroids.14C-米索硝唑与V79球体中缺氧细胞的结合。
Br J Cancer. 1982 May;45(5):694-9. doi: 10.1038/bjc.1982.110.
7
Binding of misonidazole to hypoxic cells in monolayer and spheroid culture: evidence that a side-chain label is bound as efficiently as a ring label.米索硝唑在单层和球体培养中与缺氧细胞的结合：侧链标记物与环标记物结合效率相同的证据。
Br J Cancer. 1985 Feb;51(2):229-35. doi: 10.1038/bjc.1985.33.
8
Cytotoxicity of misonidazole in vivo under conditions of prolonged contact of drug with the tumour cells.在药物与肿瘤细胞长时间接触的条件下，米索硝唑在体内的细胞毒性。
Br J Radiol. 1979 Nov;52(623):893-6. doi: 10.1259/0007-1285-52-623-893.
9
Effects of local hyperthermia on the pharmacokinetics of misonidazole in the anaesthetized mouse.局部热疗对麻醉小鼠体内米索硝唑药代动力学的影响。
Br J Cancer. 1980 Apr;41(4):529-40. doi: 10.1038/bjc.1980.95.
10
Effects of pretreatment with phenobarbitone and phenytoin on the pharmacokinetics and toxicity of phenytoin on the pharmacokinetics and toxicity of misonidazole in mice.苯巴比妥和苯妥英预处理对苯妥英在小鼠体内药代动力学及米索硝唑毒性的影响。
Br J Cancer. 1979 Sep;40(3):335-53. doi: 10.1038/bjc.1979.187.
引用本文的文献
1
Understanding brain penetrance of anticancer drugs.理解抗癌药物的脑穿透性。
Neuro Oncol. 2018 Apr 9;20(5):589-596. doi: 10.1093/neuonc/noy018.
2
Mitochondrial trifunctional protein defects: clinical implications and therapeutic approaches.线粒体三功能蛋白缺陷：临床意义与治疗方法
Adv Drug Deliv Rev. 2008 Oct-Nov;60(13-14):1488-96. doi: 10.1016/j.addr.2008.04.014. Epub 2008 Jul 4.
3
Heuristic modeling of drug delivery to malignant brain tumors.恶性脑肿瘤药物递送的启发式建模
J Pharmacokinet Biopharm. 1980 Jun;8(3):257-96. doi: 10.1007/BF01059646.
4
Local blood-to-tissue transport in Walker 256 metastatic brain tumors.Walker 256转移性脑肿瘤中的局部血液到组织的转运
J Neurooncol. 1984;2(3):205-18. doi: 10.1007/BF00253272.
5
Pharmacokinetics in experimental and clinical chemotherapy.实验性与临床化疗中的药代动力学
Cancer Chemother Pharmacol. 1986;16(2):198-9. doi: 10.1007/BF00256177.
6
The effect of dexamethasone on vascular permeability of experimental brain tumours.地塞米松对实验性脑肿瘤血管通透性的影响。
Acta Neuropathol. 1986;69(3-4):288-94. doi: 10.1007/BF00688307.
本文引用的文献
1
2
In vitro evaluation of in vivo brain tumor chemotherapy with 1,3-bis(2-chloroethyl)-1-nitrosourea.1,3-双（2-氯乙基）-1-亚硝基脲对体内脑肿瘤化疗的体外评估
Cancer Res. 1975 Jun;35(6):1387-91.
3
The application of brain capillary permeability coefficient measurements to pathological conditions and the selection of agents which cross the blood-brain barrier.
J Pharmacokinet Biopharm. 1976 Dec;4(6):499-519. doi: 10.1007/BF01064555.
4
Relationship of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) pharmacokinetics of uptake, distribution, and tissue/plasma partitioning in rat organs and intracerebral tumors.1,3-双（2-氯乙基）-1-亚硝基脲（卡莫司汀，BCNU）与1-（2-氯乙基）-3-环己基-1-亚硝基脲（洛莫司汀，CCNU）在大鼠器官和脑肿瘤中的摄取、分布及组织/血浆分配的药代动力学关系
Cancer Chemother Pharmacol. 1978;1(4):233-42. doi: 10.1007/BF00257156.
Zotero 插件