Honma Y, Okabe J, Kasukabe T, Hozumi M
Gan. 1980 Aug;71(4):543-7.
The effect of injection of an inducer and sensitizer on the survival times of syngeneic SL mice inoculated with resistant mouse myeloid leukemia cells (Ml) was examined. In vitro, the resistant Ml cells could not be induced to differentiate into mature macrophages and granulocytes by inducer (certain proteins, bacterial lipopolysaccharides, or glucocorticoids) alone, but could be induced to differentiate by treatment with both the inducer and a sensitizer (actinomycin D). In vivo, lipopolysaccharide alone scarcely affected the survival of SL mice inoculated with the resistant cells, but lipopolysaccharide plus actinomycin D significantly prolonged their survival. Administration of both lipopolysaccharide and actinomycin D also prolonged the survival of athymic nude mice inoculated with resistant Ml cells. These results suggest that prolongation of the survival of SL mice inoculated with resistant Ml cells is associated with the induction of differentiation of the cells.
研究了注射诱导剂和致敏剂对接种抗药小鼠髓性白血病细胞（Ml）的同基因SL小鼠存活时间的影响。在体外，单独使用诱导剂（某些蛋白质、细菌脂多糖或糖皮质激素）不能诱导抗药Ml细胞分化为成熟的巨噬细胞和粒细胞，但同时使用诱导剂和致敏剂（放线菌素D）处理可诱导其分化。在体内，单独的脂多糖几乎不影响接种抗药细胞的SL小鼠的存活，但脂多糖加放线菌素D可显著延长其存活时间。同时给予脂多糖和放线菌素D也延长了接种抗药Ml细胞的无胸腺裸鼠的存活时间。这些结果表明，接种抗药Ml细胞的SL小鼠存活时间的延长与细胞分化的诱导有关。
