帕金森病的良性和恶性类型：临床与病理生理特征
Benign and malignant types of Parkinson's disease: clinical and patho-physiological characterization.
作者信息
Danielczyk W, Riederer P, Seemann D
出版信息
J Neural Transm Suppl. 1980(16):199-210. doi: 10.1007/978-3-7091-8582-7_23.
Parkinson's disease (P.D.) is characterized by two different types, a benign form found in 85% of patients and a malignant type in 15%. Computer tomography shows malignant patients, in the end stage of the disease process, to exhibit hydrocephalus internus and externus. Such patients exhibit early EEG-deterioration and pharmacotoxic psychosis. The application of neuroleptics to patients with P.D. is associated with an increase in the urinary excretion of acidic metabolites especially of 5-hydroxyindoleacetic acid. It is suggested, that this treatment might also be a useful therapeutic approach to optimizing the residual neuronal function in Parkinson's disease.
帕金森病（P.D.）有两种不同类型，85%的患者为良性形式，15%为恶性类型。计算机断层扫描显示，恶性患者在疾病进程的末期会出现内脑积水和外脑积水。这些患者早期脑电图恶化，且会出现药物毒性精神病。给帕金森病患者使用抗精神病药物会使酸性代谢产物尤其是5-羟吲哚乙酸的尿排泄增加。有人认为，这种治疗方法可能也是优化帕金森病残余神经元功能的一种有用的治疗手段。
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