Danielczyk W
J Neural Transm. 1983;56(2-3):161-76. doi: 10.1007/BF01243275.
Following 2-4 years of hospitalization, the mental and physical ability of 21 patients with typical idiopathic PD, 10 patients with atypical Parkinson's syndrome and signs of cerebral arteriosclerosis, 29 patients with MID. and 14 patients with senile dementia of the Alzheimer type were evaluated according to various rating scales. All idiopathic parkinsonian patients had suffered from the disease for over 8 years. All patients were over 70 years of age and continuously subjected to the same environment. EEG and CT was performed. A rating scale consisting of 18 items for evaluation of the mental and physical capacity and ability to cope with daily psychosocial demands was used for each patient. Statistically highly significant differences resulted between the relative good mental ability of patients with idiopathic Parkinson's syndrome, with the exception of some brief pharmacotoxic psychoses, and the lower rating scores of patients with senile dementia of Alzheimer type and multiple infarction dementia. A smaller subgroup of patients with Parkinson's syndrome and additional focal signs in the neurological status and EEG showed moderate mental functional loss and a more frequent incidence of pharmacotoxic psychoses than the patients with idiopathic PD. Just as few congruencies of mental ability were found between patients with idiopathic, typical PD and patients with senile dementia of the Alzheimer type as between idiopathic PD and MID. Permanent dementia is not characteristic of patients with typical idiopathic PD even in advanced age. It is, however, for patients with MID and SDAT.
在住院2至4年后,根据各种评定量表对21例典型特发性帕金森病患者、10例伴有非典型帕金森综合征及脑动脉硬化体征的患者、29例多发梗死性痴呆患者和14例阿尔茨海默型老年性痴呆患者的心理和身体能力进行了评估。所有特发性帕金森病患者的病程均超过8年。所有患者年龄均超过70岁,且处于相同环境。进行了脑电图和CT检查。对每位患者使用一个由18项组成的评定量表,以评估心理和身体能力以及应对日常心理社会需求的能力。结果显示,除了一些短暂的药物毒性精神病外,特发性帕金森病患者相对良好的心理能力与阿尔茨海默型老年性痴呆和多发梗死性痴呆患者较低的评定得分之间存在统计学上的高度显著差异。与特发性帕金森病患者相比,帕金森综合征患者中一小部分在神经状态和脑电图方面有额外局灶性体征的患者,其心理功能丧失程度中等,药物毒性精神病的发生率更高。特发性、典型帕金森病患者与阿尔茨海默型老年性痴呆患者之间的心理能力一致性,与特发性帕金森病患者和多发梗死性痴呆患者之间的情况一样少。即使在高龄时,永久性痴呆也不是典型特发性帕金森病患者的特征。然而,多发梗死性痴呆患者和阿尔茨海默型老年性痴呆患者则有此特征。