一种16S糖蛋白复合物在细胞黏附中的作用。
Role of a 16S glycoprotein complex in cellular adhesion.
作者信息
Schubert D, LaCorbiere M
出版信息
Proc Natl Acad Sci U S A. 1980 Jul;77(7):4137-41. doi: 10.1073/pnas.77.7.4137.
Abstract
Myogenic cells release into their culture medium a glycoprotein complex that mediates cellular adhesion. In the absence of calcium this complex has a sedimentation value of 16S; it aggregates in the presence of calcium. The 16S material both agglutinates and increases the rate of cell-substratum adhesion of a myoblast variant and inhibits the adhesion of a nerve-like cell line to culture dishes. It is also a hemagglutinin. The 16S particle is composed of glycosaminoglycans and several proteins, including fibronectin and collagen.
摘要
生肌细胞向其培养基中释放一种介导细胞黏附的糖蛋白复合物。在无钙的情况下，这种复合物的沉降值为16S；在有钙的情况下它会聚集。16S物质既能凝集成肌细胞变体并提高其与底物的黏附速率，又能抑制一种神经样细胞系与培养皿的黏附。它也是一种血凝素。16S颗粒由糖胺聚糖和几种蛋白质组成，包括纤连蛋白和胶原蛋白。
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