大鼠肾肉瘤细胞系的10种转移变异衍生物的自发转移潜能、细胞表面提取物的血小板聚集活性与细胞表面唾液酸化之间的相关性。
Correlation between spontaneous metastatic potential, platelet-aggregating activity of cell surface extracts, and cell surface sialylation in 10 metastatic-variant derivatives of a rat renal sarcoma cell line.
作者信息
Pearlstein E, Salk P L, Yogeeswaran G, Karpatkin S
出版信息
Proc Natl Acad Sci U S A. 1980 Jul;77(7):4336-9. doi: 10.1073/pnas.77.7.4336.
Abstract
Several properties of 10 cell lines derived from the polyoma-induced PW20 Wistar-Furth rat renal sarcoma have been examined, including the ability of the tumor cells to metastasize spontaneously from subcutaneous sites in syngeneic hosts, the platelet-aggregating activity of material extracted by urea from the surface of cultured cells, the sialic acid content of the platelet-aggregating material, and the degree of sialylation of cell surface glycoconjugates in cultured cells. A correlation has been observed among all of these parameters. The results suggest a possible link between the degree of cell surface sialylation of tumor cells, their ability to aggregate platelets, and their ability to metastasize.
摘要
对源自多瘤病毒诱导的PW20 Wistar-Furth大鼠肾肉瘤的10个细胞系的若干特性进行了检测，包括肿瘤细胞在同基因宿主中从皮下部位自发转移的能力、用尿素从培养细胞表面提取的物质的血小板聚集活性、血小板聚集物质的唾液酸含量以及培养细胞中细胞表面糖缀合物的唾液酸化程度。在所有这些参数之间观察到了相关性。结果表明肿瘤细胞的细胞表面唾液酸化程度、它们聚集血小板的能力以及它们转移的能力之间可能存在联系。
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Correlation between spontaneous metastatic potential, platelet-aggregating activity of cell surface extracts, and cell surface sialylation in 10 metastatic-variant derivatives of a rat renal sarcoma cell line.大鼠肾肉瘤细胞系的10种转移变异衍生物的自发转移潜能、细胞表面提取物的血小板聚集活性与细胞表面唾液酸化之间的相关性。
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