Ovtcharov R, Guentcheva G, Michailova S
Arch Toxicol Suppl. 1980;4:120-31. doi: 10.1007/978-3-642-67729-8_27.
The paper deals with the experimental testing of drugs for immunotoxicity. Pharmacological substances used in the medical practice for long periods of time have been studied. The preliminary screening of drugs for possible immunotoxic effect consists of examination of its effects on the weight of lymphoid organs (spleen and thymus), on antibody production (plaque-forming cells and serum hemagglutinins), on serum levels of IgG and IgM and on serum complement (in vivo and in vitro). The toxicological appraisal of the results from this first step screening gives ground for further and more detailed studies on the substances that present interesting properties with regard to the modification of immune system.
本文论述了药物免疫毒性的实验测试。对长期用于医学实践的药理物质进行了研究。药物潜在免疫毒性作用的初步筛选包括检测其对淋巴器官（脾脏和胸腺）重量、抗体产生（空斑形成细胞和血清血凝素）、血清IgG和IgM水平以及血清补体（体内和体外）的影响。对第一步筛选结果的毒理学评估为进一步更详细地研究那些在免疫系统调节方面具有有趣特性的物质提供了依据。
