The effect of DDVP, an organophosphorus pesticide on the humoral and cell-mediated immunity of rabbits.

The effect of daily oral administration of LD50 1/40, 1/20 and 1/10 of an organophosphate pesticide DDVP (Dichlorvos) was studied in rabbits for its effect on the humoral immune response after vaccination with Salmonella typhi, as well as on cell-mediated immunity. Serum antibody titers of treated animals showed a dose-dependent fall compared with the controls. The skin redness measured in the tuberculin test showed the same dose-dependent tendency.