Wysocki J, Kalina Z, Owczarzy I
Int Arch Occup Environ Health. 1987;59(1):63-71. doi: 10.1007/BF00377680.
Investigations have been undertaken to determine the effect of occupational exposure to organophosphoric pesticides on the behaviour of NBT-dye reduction and spontaneous E rosette formation tests. A significant decrease of the values of the examined cellular parameters of human immunity and of the absolute lymphocyte count in peripheral blood was found in 31 workers, as compared to 30 controls. Moreover, the NBT-dye reduction decrease showed a positive linear correlation with a reduced acetylcholinesterase (AChE) activity. The exposure time showed a negative linear correlation of the phagocytic index of the NBT-dye reduction test. It is concluded that depressed NBT-dye reduction and diminished spontaneous E rosette formation may be regarded as a probable mode of the effect of organophosphoric chemicals on metabolic and membrane damage of human cells. A possible role of endogenous acetylcholine poisoning in the development of these pathologic conditions is also discussed.
已开展调查以确定职业性接触有机磷农药对硝基蓝四氮唑（NBT）染料还原试验行为及自发性E玫瑰花结形成试验的影响。与30名对照者相比，在31名工人中发现人体免疫的检测细胞参数值及外周血绝对淋巴细胞计数显著降低。此外，NBT染料还原降低与乙酰胆碱酯酶（AChE）活性降低呈正线性相关。暴露时间与NBT染料还原试验的吞噬指数呈负线性相关。得出的结论是，NBT染料还原降低和自发性E玫瑰花结形成减少可能被视为有机磷化学物质对人体细胞代谢和膜损伤影响的一种可能方式。还讨论了内源性乙酰胆碱中毒在这些病理状况发展中的可能作用。
