药物肾毒性检测。一般原则和最低标准。

Testing of drugs for nephrotoxicity. General principles and minimal criteria.

作者信息

Bräunlich H

出版信息

Arch Toxicol Suppl. 1980;4:233-6. doi: 10.1007/978-3-642-67729-8_48.

Abstract

A programme for testing of drugs for nephrotoxicity is described. The characterization of nephrotoxic effects is possible using a selection of morphological and physiological methods. The validity of the different methods is discussed. The measurement of renal enzyme excretion is a very sensitive method for the detection of an injury of kidney. Alterations of renal excretion of electrolytes and p-aminohippurate can be measured in a simple diuresis study.

摘要

描述了一个用于测试药物肾毒性的程序。使用一系列形态学和生理学方法可以对肾毒性作用进行表征。讨论了不同方法的有效性。测量肾脏酶排泄是检测肾脏损伤的一种非常敏感的方法。在简单的利尿研究中可以测量电解质和对氨基马尿酸盐的肾脏排泄变化。