胚胎毒性和致畸性三步试验方案的经验

Experiences with a three step test scheme for embryotoxicity and teratogenicity.

作者信息

Heinecke H, Klaus S, Güttner J

出版信息

Arch Toxicol Suppl. 1980;4:289-91. doi: 10.1007/978-3-642-67729-8_58.

Abstract

Experiences with the three step teratological screening test for selection of teratogenic side effects are described. Step I: The prenatal examination of the foetuses may give indications of embryotoxicity, growth retardation and teratogenicity. Step II: The peri- and postnatal examination includes the duration of pregnancy, the delivery, the viability, the postnatal development and behaviour of the untreated offspring. In special cases the transplacental tumour induction may be studied. Step III: The fertility of the untreated offspring is examined and, in some cases, the generation test should be added.

摘要

描述了用于筛选致畸副作用的三步致畸学筛查试验的经验。第一步：对胎儿进行产前检查可提示胚胎毒性、生长迟缓及致畸性。第二步：围产期和产后检查包括孕期时长、分娩情况、生存能力、未处理后代的产后发育及行为。在特殊情况下，可研究经胎盘的肿瘤诱导情况。第三步：检查未处理后代的生育能力，某些情况下应增加世代试验。