Smits-van Prooije A E, Waalkens-Berendsen D H, Bär A
TNO-Nutrition and Food Research Institute, Zeist, The Netherlands.
Regul Toxicol Pharmacol. 1996 Oct;24(2 Pt 2):S232-6. doi: 10.1006/rtph.1996.0103.
The embryotoxicity/teratogenicity of erythritol, a low-calorie polyol sugar substitute, was examined in Wistar Crl:(WI) WU BR rats. Erythritol was fed at dietary concentrations of 0, 2.5, 5, and 10% to groups of 32 female rats from Day 0 to 21 of gestation. The treatment was generally well tolerated and no mortality occurred in any group. Weight gain during gestation, food consumption, and food efficiency were similar in all groups except for a significantly reduced weight gain in the 10% erythritol group in Week 2 of gestation. Reproductive performance was not affected by the treatment but the fertility index was generally rather low (69% in both control and high-dose group). Examination of the fetuses for external, visceral, and skeletal alterations did not reveal any fetotoxic, embryotoxic, or teratogenic effects. The slightly lower maternal body weight in the high-dose group was interpreted as a trivial result of the consumption of a low-calorie test substance in high amounts. In conclusion, no adverse effects were observed at erythritol doses of up to about 6.6 g/kg body wt/day, i.e., the highest dose tested.
在Wistar Crl:(WI) WU BR大鼠中检测了低热量多元醇甜味剂赤藓糖醇的胚胎毒性/致畸性。从妊娠第0天至第21天，将赤藓糖醇以0%、2.5%、5%和10%的膳食浓度喂给32只雌性大鼠组成的几组。该处理一般耐受性良好，任何组均未发生死亡。除妊娠第2周10%赤藓糖醇组体重增加显著减少外，所有组妊娠期间的体重增加、食物消耗和食物效率均相似。生殖性能未受该处理影响，但生育指数总体较低（对照组和高剂量组均为69%）。对胎儿进行外部、内脏和骨骼改变检查未发现任何胎儿毒性、胚胎毒性或致畸作用。高剂量组母体体重略低被解释为大量食用低热量受试物质的轻微结果。总之，在高达约6.6 g/kg体重/天的赤藓糖醇剂量下未观察到不良影响，即所测试的最高剂量。
