Lewerenz H J, Bleyl D W
Arch Toxicol Suppl. 1980;4:292-5. doi: 10.1007/978-3-642-67729-8_59.
Ethylenethiourea (ETU), a manufacturing, processing, and metabolic product of the ethylenebisdithiocarbamate fungicides, was evaluated for its effects on postnatal performance of rats. ETU was given to pregnant rats as a single oral dose of 1-50 mg/kg on day 17, 18, 19, or 20 of gestation. The number of stillborn rats was significantly increased at dose levels of 30 and 50 mg/kg. Treatment of dams with 50 mg/kg on day 20 of gestation caused reduction in the birth weight of the offspring. Progeny survival was impaired after maternal treatment with doses of 10 mg/kg and more. The high mortality was attributable to the development of hydrocephalus in the pups. At 6 months of age, 16 and 26% of the surviving offspring from dams treated with 10 or 20 mg/kg had hydrocephalus.
乙撑硫脲（ETU）是一种乙撑双二硫代氨基甲酸盐类杀菌剂的生产、加工及代谢产物，对其对大鼠产后性能的影响进行了评估。在妊娠第17、18、19或20天，给怀孕大鼠单次口服1-50毫克/千克的ETU。在30和50毫克/千克的剂量水平下，死产大鼠的数量显著增加。在妊娠第20天用50毫克/千克处理母鼠会导致后代出生体重降低。母体用10毫克/千克及以上剂量处理后，后代存活率受损。高死亡率归因于幼崽脑积水的发展。在6个月大时，用10或20毫克/千克处理的母鼠所存活的后代中，分别有16%和26%患有脑积水。
